Development Model of Micro vascular Network in Porous Silk Fibroin Film

Within 10 days after implantation of Porous silk fibroin film (PSFF) into hypodermal tissue of rat, it was observed that the micro vascular network system had been formed in materials [1] and the arterioles were found in materials, which shows that in the process of capillary formation, the arterioles development is also underway simultaneously [2,3]. There are a lot of reports about the angiogenesis so far, in which the main focus is on the angiogenesis mechanism [1], the proliferation and growth behavior of endothelial cells and the stimulation mechanism [2] and the angiogenesis mode [3] etc. However, the relevant reports about the construction of micro vascular networks in implant materials were seldom seen. We do not know what mechanism makes the newborn capillaries develop into sound micro vascular networks within a short period of time, which have a suitable micro vessel density and a coordinated structure of vascular network to meet the metabolic demands of tissues. In the process of damaged tissue repair, this is an important issue related to whether the survival of the tissues in implant material. This study focuses on this issue, through the experiments implanting PSFFs into muscle tissue of rat, the process of micro